![]() ![]() Before the infusion began, they instructed their 14 volunteers to squeeze a force sensor with their hand whenever they breathed in and release it when they breathed out. So the team found a different, little-used approach first described in 2014 by sleep researchers. For that reason, too, they needed a method of assessing consciousness that didn't require sounds that could confound the results. Louis to test whether a method of closed loop acoustic stimulation can augment the effects of dexmedetomidine-mediated sedation. ![]() Moreover, Guay is part of a collaboration with co-authors and former colleagues at Washington University in St. ![]() "We think that conscious state transitions are interesting because they are very dynamic in the brain, but the neural mechanisms mediating these transitions aren't fully understood, in part because of how we are assessing the transitions." Guay is a research collaborator at the Neuroscience Statistics Research Laboratory in The Picower Institute for Learning and Memory at MIT, and an anesthesiologist and critical care fellow at Massachusetts General Hospital (MGH). "We want to measure when people make the transition from conscious to unconscious, and vice versa, but as soon as you ask someone to do something, which is the classic way of assessing this, you've now influenced them and disrupted the process," said Christian Guay, lead author of the study in the British Journal of Anaesthesia. ![]()
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